Chromophore Supply Rate-Limits Mammalian Photoreceptor Dark Adaptation
نویسندگان
چکیده
منابع مشابه
Chromophore supply rate-limits mammalian photoreceptor dark adaptation.
Efficient regeneration of visual pigment following its destruction by light is critical for the function of mammalian photoreceptors. Here, we show that misexpression of a subset of cone genes in the rd7 mouse hybrid rods enables them to access the normally cone-specific retina visual cycle. The rapid supply of chromophore by the retina visual cycle dramatically accelerated the mouse rod dark a...
متن کاملRod photoreceptor dysfunction in diabetes: activation, deactivation, and dark adaptation.
PURPOSE To examine photoreceptor function in diabetes in detail by evaluating photoreceptor light activation, deactivation of the photoresponse, and recovery of the photoreceptor after bleaching (dark adaptation) in rats made diabetic with streptozotocin (STZ). METHODS Animals were assigned to treated and control groups. Light activation in rod photoreceptors was established using a paired-fl...
متن کاملRetinol dehydrogenase 8 and ATP-binding cassette transporter 4 modulate dark adaptation of M-cones in mammalian retina.
KEY POINTS This study explores the molecular mechanisms that regulate the recycling of chromophore required for pigment regeneration in mammalian cones. We report that two chromophore binding proteins, retinol dehydrogenase 8 (RDH8) and photoreceptor-specific ATP-binding cassette transporter (ABCA4) accelerate the dark adaptation of cones, first, directly, by facilitating the processing of chro...
متن کاملPhotoreceptor Light Adaptation
The illumination at the earth’s surface varies by . 10 orders of magnitude during the normal day–night cycle, and the vertebrate visual system covers this entire range of light intensities with two neuronal subsystems that rely on the activity of two types of photoreceptor cells, rods and cones. Human rod vision operates over approximately seven decimal orders of illumination. The cone visual s...
متن کاملLow aqueous solubility of 11-cis-retinal limits the rate of pigment formation and dark adaptation in salamander rods
We report experiments designed to test the hypothesis that the aqueous solubility of 11-cis-retinoids plays a significant role in the rate of visual pigment regeneration. Therefore, we have compared the aqueous solubility and the partition coefficients in photoreceptor membranes of native 11-cis-retinal and an analogue retinoid, 11-cis 4-OH retinal, which has a significantly higher solubility i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2014
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1245-14.2014